Genetic Diversity and Drug Susceptibility Profiles of Multidrug-Resistant Tuberculosis Strains in Southeast China.
Shufang LinShuzhen WeiYong ZhaoZhisong DaiJian LinYu PangPublished in: Infection and drug resistance (2021)
Our data demonstrate that the Beijing genotype is the dominant lineage among MDR-TB strains circulating in Fujian. Thus, MDR-TB infections occurring within this province are not likely associated with recent transmission events. PZA and fluoroquinolone resistance profiles were found to be associated with clustered isolates. Mutation of pncA is the main driver of MDR-TB PZA resistance and is associated with mutation sites scattered throughout the entire pncA protein-coding region.
Keyphrases
- multidrug resistant
- genetic diversity
- mycobacterium tuberculosis
- drug resistant
- gram negative
- acinetobacter baumannii
- escherichia coli
- klebsiella pneumoniae
- pulmonary tuberculosis
- air pollution
- south africa
- particulate matter
- small molecule
- protein protein
- single cell
- emergency department
- big data
- artificial intelligence
- cystic fibrosis
- hepatitis c virus
- data analysis
- pseudomonas aeruginosa
- human immunodeficiency virus
- hiv infected