Phase 2 study of glucarpidase in patients with delayed methotrexate elimination after high-dose methotrexate therapy.

Atsushi OgawaHiroshi KawamotoJunichi Hara Atsushi KikutaChitose OgawaHiroaki HiragaKenichi YoshimuraKazunari MiyairiReiko OmoriTokihiro RoYuna KameiToshimi Kimura

Published in: Cancer chemotherapy and pharmacology (2024)

Glucarpidase showed an effect of reducing plasma MTX concentration in Japanese patients with DME as that observed in a previous US study, confirming its favorable safety and tolerability.

Keyphrases

high dose
open label
stem cell transplantation
low dose
double blind
placebo controlled
clinical trial
stem cells