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Homologous tropomyosins from vertebrate and invertebrate: Recombinant calibrator proteins in functional biological assays for tropomyosin allergenicity assessment of novel animal foods.

Julia KlueberJoana CostaStefanie RandowFrançoise Codreanu-MorelKitty VerhoeckxCarsten Bindslev-JensenMarkus OllertKarin Hoffmann-SommergruberMartine MorissetThomas HolzhauserAnnette Kuehn
Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2019)
According to current GM crops' allergenicity assessment, non-allergenic chicken TM could falsely be considered an allergen on a weight-of-evidence approach. However, calibrating allergenic potency in functional BAT and RBL cell assays with clinically validated TMs allowed for semi-quantitative discrimination of novel food protein's allergenicity. With TM calibration as a proof of concept, similar systems of homologous protein might be developed to scale on an axis of allergenicity.
Keyphrases
  • dna repair
  • dna damage
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  • single cell
  • body mass index
  • amino acid
  • cell therapy
  • physical activity
  • high resolution
  • stem cells
  • low cost