B Cells in the CNS at Postmortem Are Associated With Worse Outcome and Cell Types in Multiple Sclerosis.
Marcello MocciaLukas HaiderE Ann YehSteven Harry Pieter van de PavertVincenzo Brescia MorraAmy PatelClaudia Angela Michela Wheeler-KingshottFrederik BarkhofOlga CiccarelliPublished in: Neurology(R) neuroimmunology & neuroinflammation (2021)
Perivascular B cells were associated with worse clinical outcomes and CNS-compartmentalized inflammation. Our findings further support the concept of targeting compartmentalized B-cell inflammation in progressive MS.