Metabolomic and transcriptomic profiling of adult mice and larval zebrafish leptin mutants reveal a common pattern of changes in metabolites and signaling pathways.
Yi DingMariëlle C HaksGabriel Forn-CuníJunling HeNatalia NowikAmy C HarmsThomas HankemeierMuhamed N H EezaJörg MatysikA AliaHerman P SpainkPublished in: Cell & bioscience (2021)
Leptin deficiency leads to highly similar metabolic alterations in metabolites in both mice and zebrafish larvae. These metabolic changes show similar features as observed during progression of tuberculosis in human patients, mice and zebrafish larvae. In addition, by studying the transcriptome, we found similar changes in gene regulation related to proteolysis and arachidonic acid metabolism in these two different in vivo models.
Keyphrases
- single cell
- high fat diet induced
- end stage renal disease
- ms ms
- rna seq
- endothelial cells
- signaling pathway
- wild type
- drosophila melanogaster
- chronic kidney disease
- genome wide
- mycobacterium tuberculosis
- ejection fraction
- peritoneal dialysis
- gene expression
- prognostic factors
- insulin resistance
- emergency department
- metabolic syndrome
- hiv aids
- patient reported outcomes
- skeletal muscle
- type diabetes
- young adults
- oxidative stress
- pulmonary tuberculosis
- induced pluripotent stem cells
- adipose tissue
- hiv infected