Radiotherapy Advances in Renal Disease-Focus on Renal Ischemic Preconditioning.
Badr KhbouzShiyang GuTiago Pinto CoelhoFrançois LallemandFrançois JouretPublished in: Bioengineering (Basel, Switzerland) (2023)
Ionizing irradiation is widely applied as a fundamental therapeutic treatment in several diseases. Acute kidney injury (AKI) represents a global public health problem with major morbidity and mortality. Renal ischemia/reperfusion (I/R) is the main cause of AKI. I/R injury occurs when blood flow to the kidney is transiently interrupted and then restored. Such an ischemic insult significantly impairs renal function in the short and long terms. Renal ischemic preconditioning (IPC) corresponds to the maneuvers intended to prevent or attenuate the ischemic damage. In murine models, irradiation-induced preconditioning (IP) renders the renal parenchyma resistant to subsequent damage by activating defense pathways involved in oxidative stress, angiogenesis, and inflammation. Before envisioning translational applications in patients, safe irradiation modalities, including timing, dosage, and fractionation, need to be defined.
Keyphrases
- oxidative stress
- ischemia reperfusion injury
- acute kidney injury
- cerebral ischemia
- blood flow
- public health
- diabetic rats
- radiation induced
- end stage renal disease
- chronic kidney disease
- cardiac surgery
- low dose
- dna damage
- newly diagnosed
- endothelial cells
- ejection fraction
- brain injury
- blood brain barrier
- early stage
- signaling pathway
- induced apoptosis
- locally advanced
- drug induced
- replacement therapy
- patient reported
- heat shock protein