YAP and the RhoC regulator ARHGAP18, are required to mediate flow-dependent endothelial cell alignment.
Paul R ColemanAngelina J LayKa Ka TingYang ZhaoJia LiSorour JarrahMathew A VadasJennifer R GamblePublished in: Cell communication and signaling : CCS (2020)
Our results show that YAP is downstream of ARHGAP18 in mature endothelial cells and that this pathway is involved in the athero-protective alignment of endothelial cells under laminar shear stress. ARHGAP18 depletion leads to a disruption of the junctions as seen by loss of VE-Cadherin localisation to these regions and a concomitant localisation of YAP to the nucleus.