T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas.
Michael KilianMirco FriedrichKhwab SanghviEdward GreenStefan PuschDaisuke KawauchiMartin LöwerJana K SonnerChristopher KrämerJulia ZamanStefanie JungMichael O BreckwoldtGerald WillimksyStefan B EichmüllerAndreas von DeimlingWolfgang WickFelix SahmMichael PlattenLukas BunsePublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
The integration of immunocompetent MHC-humanized orthotopic glioma models in the discovery of shared immunogenic glioma neoepitopes facilitates the identification and preclinical testing of human leukocyte antigen (HLA)-restricted neoepitope-specific TCRs for locoregional TCR-transgenic T-cell adoptive therapy.