Nickel(IV)-Catalyzed C-H Trifluoromethylation of (Hetero)arenes.
Elizabeth A MeucciShay N NguyenNicole M CamassoEugene ChongAlireza AriafardAlison J CantyMelanie S SanfordPublished in: Journal of the American Chemical Society (2019)
This Article describes the development of a stable NiIV complex that mediates C(sp2)-H trifluoromethylation reactions. This reactivity is first demonstrated stoichiometrically and then successfully translated to a NiIV-catalyzed C-H trifluoromethylation of electron-rich arene and heteroarene substrates. Both experimental and computational mechanistic studies support a radical chain pathway involving NiIV, NiIII, and NiII intermediates.