Primary mitochondrial diseases: The intertwined pathophysiology of bioenergetic dysregulation, oxidative stress and neuroinflammation.
Kevin AguilarPatrycja JakubekAntonio ZorzanoMariusz Roman WieckowskiPublished in: European journal of clinical investigation (2024)
In summary, this review provides a comprehensive overview of bioenergetic alterations and redox imbalance in cellular models of PMDs while underscoring the significance of neuroinflammation as a potential driver in disease progression.
Keyphrases
- oxidative stress
- lipopolysaccharide induced
- lps induced
- traumatic brain injury
- cognitive impairment
- cerebral ischemia
- dna damage
- diabetic rats
- inflammatory response
- ischemia reperfusion injury
- induced apoptosis
- human health
- signaling pathway
- subarachnoid hemorrhage
- blood brain barrier
- risk assessment
- climate change
- heat shock