Antiphospholipid antibody-induced trophoblast responses are differentially modulated by viral dsRNA and viral ssRNA.
Rachel A DeSpenzaDeidre M JonesLawrence Willam ChamleyVikki M AbrahamsPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2021)
While viral ssRNA may have some protective effects on aPL-induced inflammation and anti-angiogenic responses, viral dsRNA exacerbated aPL-mediated inflammation and viral ssRNA further limited cell migration, which could prove detrimental to placentation. Thus, viral infections may contribute to adverse pregnancy outcomes in women with aPL.