The effect of herpes simplex virus vector-mediated gene therapy of protein phosphatase 1α on bladder overactivity and nociception.

Tsuyoshi MajimaKenichi MoriKatsumi KadekawaShun TakaiYasuhito FunahashiBonnie ReinhartWilliam F GoinsMomokazu GotohJoseph C GloriosoEi-Ichiro Takaoka

Published in: Neurourology and urodynamics (2018)

HSV vectors-mediated PP1α gene therapy may be an alternative treatment modality for cystitis-related hypersensitive bladder condition at least in part via modulation of the IP3 R signaling pathway.

Keyphrases

gene therapy
herpes simplex virus
signaling pathway
spinal cord injury
urinary tract
pi k akt
epithelial mesenchymal transition
oxidative stress
cell proliferation
botulinum toxin
drug induced