Spread of the bla OXA-48 /IncL Plasmid within and between Dogs in City Parks, France.
Marisa HaenniVéronique MétayerAgnese LupoAntoine DrapeauJean-Yves MadecPublished in: Microbiology spectrum (2022)
The bla OXA-48 /IncL plasmid is increasingly reported in dogs, even in the absence of carbapenem use in animals. In this study, we witnessed the spread of this plasmid within and between dogs sharing the same relaxing area. This indicates a very dynamic situation where carbapenem resistance can be transmitted between dogs and expanded in the dogs' gut. As a consequence, picking up dog feces may lower both this dynamic and the global antimicrobial resistance burden. IMPORTANCE The use of carbapenems in animals is forbidden in France due to their critical importance to treat human diseases. Nevertheless, bla OXA-48 -producing Enterobacterales were sporadically recovered in cats and dogs, most likely as a spill over from the human reservoir. This study highlights the rapid spread of bla OXA-48 once transmitted to dogs, suggesting that companion animals can play a role in the transmission routes of carbapenemase genes.
Keyphrases
- klebsiella pneumoniae
- escherichia coli
- acinetobacter baumannii
- multidrug resistant
- antimicrobial resistance
- endothelial cells
- drug resistant
- crispr cas
- gram negative
- gene expression
- pseudomonas aeruginosa
- induced pluripotent stem cells
- social media
- dna methylation
- health information
- quantum dots
- cystic fibrosis
- sensitive detection
- loop mediated isothermal amplification