The potential use of theranostic bacteria in cancer.
Khalil AzizianInna PustokhinaRoya GhanavatiMichael R HamblinAbolfazl AminiEbrahim KouhsariPublished in: Journal of cellular physiology (2020)
Conventional chemotherapy approaches have not been fully successful in the treatment of cancer, due to limitations imposed by the pathophysiology of solid tumors, leading to nonspecific drug uptake by healthy cells, poor bioavailability, and toxicity. Thus, novel therapeutic modalities for more efficient cancer treatment are urgently required. Living bacteria can be used as a theranostic approach for the simultaneous diagnosis and therapy of tumors. Herein, we summarize the currently available literature focused on the advantages and challenges for the use of theranostic bacteria in cancer therapy.
Keyphrases
- papillary thyroid
- photodynamic therapy
- cancer therapy
- squamous cell
- fluorescence imaging
- induced apoptosis
- systematic review
- drug delivery
- oxidative stress
- emergency department
- squamous cell carcinoma
- lymph node metastasis
- stem cells
- risk assessment
- locally advanced
- radiation therapy
- human health
- signaling pathway
- combination therapy