A hidden Markov tree model for testing multiple hypotheses corresponding to Gene Ontology gene sets.

Kun LiangChuanlong DuHankun YouDan Nettleton

Published in: BMC bioinformatics (2018)

The HMTM method provides an individual estimate of posterior probability of being differentially expressed for each gene set, which can be useful for result interpretation. The R package can be found on https://github.com/k22liang/HMTGO .

Keyphrases

copy number
genome wide
genome wide identification
gene expression
transcription factor