Cardiovascular disease in hereditary haemophilia: The challenges of longevity.
Susan ShapiroGary BensonGillian EvansCatherine HarrisonSarah ManglesMike MakrisPublished in: British journal of haematology (2022)
The development of effective and safe treatments has significantly increased the life expectancy of persons with haemophilia (PWH). This has been accompanied by an increase in the comorbidities of ageing including cardiovascular disease, which poses particular challenges due to the opposing risks of bleeding from haemophilia and antithrombotic treatments versus thrombosis. Although mortality secondary to coronary artery disease in PWH is less than in the general population, the rate of atherosclerosis appears similar. The prevalence of atrial fibrillation in PWH and risk of secondary thromboembolic stroke are not well established. PWH can be safely supported through acute coronary interventions but data on the safety and efficacy of long-term antithrombotics are scarce. Increased awareness and research on cardiovascular disease in PWH will be crucial to improve primary prevention, acute management, secondary prevention and to best support ageing PWH.
Keyphrases
- cardiovascular disease
- atrial fibrillation
- coronary artery disease
- cardiovascular events
- liver failure
- oral anticoagulants
- catheter ablation
- left atrial
- left atrial appendage
- respiratory failure
- percutaneous coronary intervention
- direct oral anticoagulants
- type diabetes
- cardiovascular risk factors
- coronary artery
- heart failure
- drug induced
- physical activity
- aortic dissection
- pulmonary embolism
- coronary artery bypass grafting
- electronic health record
- machine learning
- big data
- human health
- climate change
- artificial intelligence
- aortic valve
- left ventricular
- mechanical ventilation