Epigenomic mapping in B-cell acute lymphoblastic leukemia identifies transcriptional regulators and noncoding variants promoting distinct chromatin architectures.
Kelly R BarnettRobert Jackson MobleyJonathan D DiedrichBrennan P BergeronKashi Raj BhattaraiWenjian YangKristine R CrewsChristopher S ManringElias JabbourElisabeth PaiettaMark R LitzowSteven M KornblauWendy StockHiroto InabaSima JehaChing-Hon PuiCharles G MullighanMary V RellingJun J YangWilliam E EvansDaniel SavicPublished in: bioRxiv : the preprint server for biology (2023)
-regulatory rewiring in B-ALL Subtype-specific accessible chromatin signatures representing 20% of all B-ALL sitesRole for distinct TFs in promoting subtype-specific chromatin architecturesThousands of inherited genetic variants identified impacting chromatin state.