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Enantioselective Hydroalkoxylation of 1,3-Dienes via Ni-Catalysis.

Qi LiZhen WangVy M DongXiao-Hui Yang
Published in: Journal of the American Chemical Society (2023)
As an advance in hydrofunctionalization, we herein report that alcohols add to 1,3-dienes with high regio- and enantioselectivity. Using Ni-DuPhos, we access enantioenriched allylic ethers. Through the choice of solvent-free conditions, we control the reversibility of C-O bond formation. This work showcases a rare example of methanol as a reagent in asymmetric synthesis.
Keyphrases
  • transition metal
  • metal organic framework
  • ionic liquid
  • carbon dioxide
  • visible light