Recent Advances in Polymer Microneedles for Drug Transdermal Delivery: Design Strategies and Applications.
Rui WangGuohua JiangUladzislau E AharodnikauKhaydar YunusovYanfang SunTianqi LiuSergey O SolomevichPublished in: Macromolecular rapid communications (2022)
In recent years, transdermal drug delivery based on microneedles (MNs) technology has received extensive attention, which offers a safer and painless alternative to hypodermic needle injections. They can pierce the stratum corneum and deliver drugs to the epidermis and dermis-structures of skin, showing prominent properties such as minimally invasiveness, bypassing first-pass metabolism, and can be self-administered. A range of materials has been used to fabricate MNs, such as silicon, metal, glass, and polymers. Among them, polymer MNs have gained increasing attention from pharmaceutical and cosmetic companies as one of the promising drug delivery methods. MN products have recently become available on the market, and some of them are under evaluation for efficacy and safety. This paper focuses on the current state of polymer MNs in drug transdermal delivery. The materials and methods for the fabrication of polymer MNs and their drug administration are described. The recent progress of polymer MNs for treatment of cancer, vaccine delivery, blood glucose regulation, androgenetic alopecia, obesity, tissue healing, myocardial infarction, and gout are reviewed. The challenges of MNs technology are summarized and the future development trend of MNs is also prospected.
Keyphrases
- drug delivery
- blood glucose
- heart failure
- working memory
- type diabetes
- drug administration
- weight loss
- cancer therapy
- high resolution
- ultrasound guided
- squamous cell carcinoma
- left ventricular
- body mass index
- platelet rich plasma
- current status
- physical activity
- blood pressure
- weight gain
- adipose tissue
- drug induced
- young adults
- adverse drug
- glycemic control
- skeletal muscle
- high fat diet induced
- drug release