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Structural Diversification of Pyrazinone Metabolites via Spontaneous Oxa-Michael Addition in Staphylococcus xylosus .

Ju Ryeong LeeSu Jung HwangYukyung ChoiJonghwan KimGyu Sung LeeBum Soo LeeKi Hyun KimKyo-Bin KangHyo-Jong LeeChung Sub Kim
Published in: Journal of natural products (2024)
A family of pyrazinone metabolites ( 1 - 11 ) were characterized from Staphylococcus xylosus ATCC 29971. Six of them were hydroxylated or methoxylated, which were proposed to be produced by the rare noncatalytic oxa-Michael addition reaction with a water or methanol molecule. It was confirmed that isopropyl alcohol can also be the Michael donor of the reaction. 1 - 7 and the synthetic precursor 2a showed significant inhibition of breast cancer cell migration.
Keyphrases
  • cell migration
  • acinetobacter baumannii
  • staphylococcus aureus
  • ms ms
  • biofilm formation
  • klebsiella pneumoniae
  • pseudomonas aeruginosa
  • multidrug resistant
  • drug resistant
  • carbon dioxide
  • candida albicans
  • young adults