Cardiac ischemia/reperfusion injury is inversely affected by thyroid hormones excess or deficiency in male Wistar rats.
Fernando Azevedo Cruz SearaLeonardo MacielRaiana A Q BarbosaNayana C RodriguesAnderson L B SilveiraMichelle P MarassiAdriana B CarvalhoJosé Hamilton M NascimentoEmerson L OlivaresPublished in: PloS one (2018)
Thyrotoxicosis was correlated, at least in part, to cardiac remodeling and increased susceptibility to IR injury possibly due to down-regulation of antioxidant enzymes, whereas hypothyroid hearts were less vulnerable to IR injury.