Identification of monoclonal antibodies against human renal glomerular endothelial cells in lupus nephritis that induce endothelial interferon-alpha production.

Ya-Chiao HuI-Jung TsaiHui-Yao HsuBor-Luen ChiangYao-Hsu Yang

Published in: Arthritis research & therapy (2021)

Some IgG anti-HRGEC antibodies in LN patients had the ability to enhance endothelial proinflammatory cytokine (IL-6, IL-8, and MCP-1) production, and some could induce the DNA-independent production of IFN-α by HRGEC.

Keyphrases

endothelial cells
high glucose
end stage renal disease
ejection fraction
chronic kidney disease
dendritic cells
vascular endothelial growth factor
prognostic factors
peritoneal dialysis
single molecule
patient reported outcomes
cell free
circulating tumor
diabetic nephropathy