The effect of purification of Ga-68-labeled exendin on in vivo distribution.
Maarten BromGerben M FranssenLieke JoostenMartin GotthardtOtto C BoermanPublished in: EJNMMI research (2016)
We showed that the colloid content can be measured by TLC and that solid phase extraction and HPLC completely remove (68)Ga-colloid from (68)Ga-labeled tracer preparations, resulting in very low liver and spleen uptake. This study clearly shows the importance of removal of (68)Ga-colloid from preparations.
Keyphrases
- pet ct
- solid phase extraction
- high performance liquid chromatography
- simultaneous determination
- positron emission tomography
- pet imaging
- liquid chromatography tandem mass spectrometry
- tandem mass spectrometry
- molecularly imprinted
- ms ms
- mass spectrometry
- ultra high performance liquid chromatography
- gas chromatography
- computed tomography
- high resolution