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Granular cell tumor of the neurohypophysis presenting as a third ventricle mass.

Gianluca LopezCarlo PesciaCarlo GalliManuela BramerioAntonella TosoniManuela NebuloniMariarosa FerraraGiulio BertaniLuca CascheraFabio Maria TriulziMarco LocatelliSilvia TabanoGiorgio Alberto Croci
Published in: Neuropathology : official journal of the Japanese Society of Neuropathology (2023)
Granular cell tumors of the neurohypophysis (GCT) are rare benign neoplasms belonging, along with pituicytoma and spindle cell oncocytoma, to the family of TTF1-positive low-grade neoplasms of the posterior pituitary gland. GCT usually present as a solid sellar mass, slowly growing and causing compressive symptoms over time, occasionally with suprasellar extension. They comprise polygonal monomorphous cells with abundant granular cytoplasm, which is ultrastructurally filled with lysosomes. Here we report the case of a GCT presenting as a third ventricle mass, radiologically mimicking chordoid glioma, with aberrant expression of GFAP and Annexin-A, which lends itself as an example of an integrated diagnostic approach to sellar/suprasellar and third ventricle masses.
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