Sunitinib combined with angiotensin-2 type-1 receptor antagonists induces more necrosis: a murine xenograft model of renal cell carcinoma.

Grégory VerhoestThibault Dolley-HitzeFlorence JouanMarc-Antoine Belaud-RotureauEmmanuel OgerAudrey LavenuKarim BensalahYannick Arlot-BonnemainsNicolas ColletNathalie Rioux-LeclercqCécile Vigneau

Published in: BioMed research international (2014)

The combination of sunitinib and telmisartan revealed an enhancement of the blockage of the VEGF pathway on renal tumor resulting in a decrease in neoangiogenesis and an increase in necrosis.

Keyphrases

renal cell carcinoma
vascular endothelial growth factor
metastatic renal cell carcinoma
endothelial cells
angiotensin ii
single cell
angiotensin converting enzyme