YTHDF1-mediated sphingosine kinase 2 upregulation alleviates bupivacaine-induced neurotoxicity via the PI3K/AKT axis.

Published in: Human & experimental toxicology (2024)

In sum, YTHDF1-mediated SPHK2 upregulation ameliorated BUP-induced neurotoxicity in DRG neurons via promoting activation of the PI3K/AKT signaling pathway.

Keyphrases

signaling pathway
high glucose
diabetic rats
cell proliferation
pi k akt
drug induced
spinal cord
endothelial cells
pain management
oxidative stress
tyrosine kinase
stress induced