Let Me See: Correlation between 5-ALA Fluorescence and Molecular Pathways in Glioblastoma: A Single Center Experience.
Francesco Maria Calamo SpecchiaMatteo MonticelliPietro ZeppaAndrea BianconiFrancesco ZengaRoberto AltieriBeatrice PuglieseGiuseppe Di PernaFabio CofanoFulvio TartaraLuca BerteroPaola CassoniAntonio MelcarneMichele Maria LanotteDiego GarbossaPublished in: Brain sciences (2021)
Our results do not support the use of 5-ALA as a diagnostic tool, or a way to substitute the molecular profiling, but confirm 5-ALA as a powerful metabolic tracer, able to easily detect the pathological cells, especially in the IDH WT genotype, and in this perspective, further studies will be necessary to better describe the metabolic activity of GBM cells.