TLR4 mutation protects neurovascular function and cognitive decline in high-fat diet-fed mice.
Nathalie ObadiaGiulia AndradeMarina Leardini-TristãoLetícia AlbuquerqueCelina GarciaFlavia LimaJúlio DalepraneHugo C Castro-Faria-NetoEduardo TibiriçáVanessa EstatoPublished in: Journal of neuroinflammation (2022)
Our results demonstrate that TLR4 is involved in the microvascular dysfunction and neuroinflammation associated with HFD-induced MS and possibly has a causal role in the development of cognitive decline.
Keyphrases
- cognitive decline
- high fat diet
- toll like receptor
- mild cognitive impairment
- inflammatory response
- insulin resistance
- adipose tissue
- immune response
- lipopolysaccharide induced
- high fat diet induced
- lps induced
- high glucose
- mass spectrometry
- diabetic rats
- oxidative stress
- multiple sclerosis
- traumatic brain injury
- nuclear factor
- ms ms
- drug induced
- type diabetes
- endothelial cells
- brain injury
- cerebral ischemia
- wild type
- blood brain barrier