Association of Gout Polygenic Risk Score with Age at Disease Onset and Tophaceous Disease in European and Polynesian Men with Gout.
Nicholas A SumpterRiku TakeiMurray CadzowRuth K G ToplessAmanda J Phipps-GreenRinki MurphyJanak de ZoysaHuti WatsonMuhammad QasimAlexa S LupiAbhishek AbhishekMariano AndrésTania O CrișanMichael DohertyLennart JacobssonMatthijs JanssenTim L JansenLeo A B JoostenMeliha Crnkic KapetanovicFrédéric LiotéHirotaka MatsuoGeraldine M McCarthyFernando Perez-RuizPhilip RichesPascal RichetteFlavia M CicuttiniBlanka StibůrkováAlexander SoAnne-Kathrin TauscheRosa J TorresTill UhligTanya J MajorLisa K StampNicola DalbethHyon K ChoiAna I VazquezMegan P LeaskRichard J ReynoldsTony Raymond MerrimanPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2022)
Gout risk variants also harbor risk for earlier age at onset and tophaceous disease in European and Polynesian men. Our findings suggest that earlier gout onset involves the accumulation of gout risk alleles in men but perhaps not women, and that this genetic risk is shared across multiple ancestral groups.