Polysensitization in the Spanish Contact Dermatitis Registry (REIDAC): A 2019-2022 prospective study with cluster and network analysis.

David Pesqué Leopoldo BorregoVioleta Zaragoza-NinetTatiana Sanz-SánchezFrancisco Javier Miquel-MiquelRicardo González-PérezJuan Francisco SilvestreSusana Córdoba-GuijarroY José Manuel Carrascosa Maria-Elena Gatica-OrtegaInmaculada Ruiz-GonzálezPedro Mercader-GarcíaFátima Tous RomeroFrancisco Javier Ortiz de FrutosEsther Serra-BaldrichMaria-Antonia Pastor-NietoMercedes Rodríguez-SernaJavier Sánchez-PérezAraceli Sánchez Gilo Gemma Melé-NinotPaloma Sánchez-Pedreño GuillénRamon Maria PujolGimenez-Arnau Ana Maria

Published in: Journal of the European Academy of Dermatology and Venereology : JEADV (2024)

This study confirms that PS is structured by discernible patterns of specific-allergen clusters and reinforces significant allergen associations in PS. Cross-reactivity and/or concomitant sensitization could explain the formation of allergen clusters in PS.

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