Multifunctional On-Demand Removability Hydrogel Dressing Based on In-Situ Formed AgNPs, Silk Microfibers and Hydrazide Hyaluronic Acid for Burn Wound Healing.

Elevated temperatures can deactivate tissues in the burn wound area, allowing pathogenic bacteria to multiply on the wound surface, ultimately leading to local or systemic infection. An ideal burn dressing should provide antibacterial properties and facilitate painless dressing changes. We utilized silk microfibers coated with 2, 3, 4-trihydroxybenzaldehyde (referred to as mSF@PTHB) to in situ reduce AgNO 3 to silver nanoparticles (AgNPs) in a hydrazide hyaluronic acid based hydrogel. The findings indicated a more homogeneous distribution of the silver elements compared to directly doped AgNPs, which also conferred antioxidant and antibacterial properties to the hydrogel. Moreover, hydrogels containing pH-responsive dynamic acylhydrazone bonds can undergo a gel-sol transition in a weak acid environment, leading to the painless removal of adhesive hydrogel dressings. Notably, the on-demand replaceable self-healing antioxidant hydrogel dressing exhibited antibacterial effects and cytocompatibility in vitro, and the wound healing performance of the hydrogel was validated by treating a burn mouse model with full-thickness skin defects. It has been demonstrated that hydrogel dressings offer a viable therapeutic approach to prevent infection and facilitate the healing of burn wounds. This article is protected by copyright. All rights reserved.