Curcumin@metal organic frameworks nano-composite for treatment of chronic toxoplasmosis.
Aziza A M El-ShafeyMohammed H A HegabMoshira M E SeliemAshraf M A BarakatNahed E MostafaHanem A Abdel-MaksoudReda M AbdelhameedPublished in: Journal of materials science. Materials in medicine (2020)
Toxoplasmosis is a zoonotic protozoal disease caused by Toxoplasma gondii, an intracellular opportunistic protozoan parasite that can infect any warm-blooded vertebrate cell. In this study, zirconium, and iron-based metal-organic framework was prepared according to the solvothermal method. New nanocomposite (Curcumin@MOFs) was prepared by reacting curcumin with amino-functionalized metal-organic frameworks (Fe-MOF and UiO-66-NH2). Besides characterizations of the composite by powder X-ray diffraction and scanning electron microscope, nano-Curcumin@MOFs was used as a new novel structure as atrial for treatment of chronic toxoplasmosis. Results showed a reduced number of brain cysts, high levels of serum Toxo IgG, and normal histo-morphology with preserved parenchymal, and stromal tissues in rats groups treated with curcumin and Curcumin@MOFs nanocomposite.
Keyphrases
- metal organic framework
- toxoplasma gondii
- quantum dots
- electron microscopy
- reduced graphene oxide
- atrial fibrillation
- stem cells
- magnetic resonance
- heart failure
- magnetic resonance imaging
- multiple sclerosis
- computed tomography
- gold nanoparticles
- resting state
- cell therapy
- functional connectivity
- subarachnoid hemorrhage
- mass spectrometry
- smoking cessation
- tandem mass spectrometry
- solid phase extraction
- left atrial
- aqueous solution
- visible light
- iron deficiency