Magnetron sputtered magnesium-based thin film metallic glasses for bioimplants.

Mg-based thin film metallic glasses (TFMGs) can viably decrease stress shielding caused by mismatch of the modulus of elasticity between the implant material and human bone. Here, Mg-based TFMGs were fabricated onto implantable substrates by ion assisted pulsed DC magnetron sputtering. The microstructure assessment and the impact of the principle constituents of the coatings were determined utilizing an x-ray diffractometer, a transmission electron microscope, and x-ray photoelectron spectroscopy. The hardness of these thin films was estimated to be 5.1 GPa. In vitro degradation tests including electrochemical studies and immersion tests in simulated body fluid revealed that the presence of zinc could raise the corrosion resistance of Mg-based TFMG. Indirect in vitro cytotoxicity using L929 fibroblast cells revealed that the TFMGs did not induce any toxicity in cells. Biomineralization experiments using Saos-2 cells promoted the formation of calcium phosphate on its surface.