The impact of COVID-19 on familial Mediterranean fever: a nationwide study.
Nesrin ŞenFatma Gül YurdakulHatice BodurAhmet Kıvanç CengizÜlkü UçarHasan Fatih CayNesrin ŞenYasar KeskinGülcan GürerMeltem Alkan MelikogluDuygu AltıntaşHülya DeveciMerve BaykulKemal NasRemzi CevikAli Yavuz KarahanMurat ToprakSertaç KetenciMehmet NayimoğluIlhan SezerAli Nail DemirHilal KocabaşMehmet Tuncay DuruözOzan Volkan YurdakulAyşe Banu SarıfakıoğluŞebnem AtamanPublished in: Rheumatology international (2021)
The study aimed to evaluate the impact of the coronavirus disease 2019 (COVID-19) in patients with familial Mediterranean fever (FMF) and to assess the relationships between FMF characteristics and severe COVID-19 outcomes such as hospitalization. The study was planned within a national network of 21 different centers. Demographics, FMF-related clinical and genetic characteristics, and COVID-19 outcomes were obtained. A total of 822 patients with FMF (mean age of 36 years) were included in the study. Fifty-nine of them (7%) had a COVID-19 diagnosis confirmed by real-time PCR test or chest CT findings. Most FMF patients with COVID-19 (58) had mild and moderate disease activity. All patients were on colchicine treatment. However, 8 of them (13.6%) were not compliant with colchicine use and 9 of them (15.3%) were colchicine resistant. Twelve FMF patients with COVID-19 were hospitalized. There were 4 patients requiring oxygen support. COVID-19 related complications were observed in 2 patients (1 thromboembolism, 1 acute respiratory distress syndrome). Hospitalized COVID-19 patients with FMF were older than non-hospitalized patients (median ages: 51 and 31 years, respectively; p: 0.002). Other FMF-related characteristics were similar between the groups. FMF-related characteristics were not found to be associated with poor outcomes in COVID-19. Thus, FMF may not be a risk factor for poor COVID-19 outcomes.
Keyphrases
- coronavirus disease
- sars cov
- end stage renal disease
- respiratory syndrome coronavirus
- ejection fraction
- acute respiratory distress syndrome
- newly diagnosed
- disease activity
- rheumatoid arthritis
- chronic kidney disease
- systemic lupus erythematosus
- prognostic factors
- early onset
- magnetic resonance imaging
- peritoneal dialysis
- gene expression
- computed tomography
- physical activity
- patient reported outcomes
- magnetic resonance
- ankylosing spondylitis
- risk factors
- weight loss
- real time pcr
- copy number
- combination therapy
- drug induced