Extended Versus Standard Proning Duration for COVID-19 Associated Acute Respiratory Distress Syndrome: A Target Trial Emulation Study.

Chad H HochbergElizabeth ColantuoniSarina K Sahetya Michelle N EakinEddy FanKevin J PsoterTheodore J IwashynaDale M NeedhamDavid N Hager

Published in: Annals of the American Thoracic Society (2024)

Using target trial emulation, we found no significant effect of extended vs. standard proning duration on mortality, ventilator liberation, or ICU discharge. However, given the imprecision of estimates, further study is justified. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Keyphrases

acute respiratory distress syndrome
mechanical ventilation
extracorporeal membrane oxygenation
phase iii
study protocol
coronavirus disease
clinical trial
phase ii
sars cov
intensive care unit
risk factors
cardiovascular events
cardiovascular disease
coronary artery disease