Differences in Post-mRNA Vaccination SARS-CoV-2 IgG Concentrations and Surrogate Virus Neutralization Test Response by HIV Status and Type of Vaccine: a Matched Case-Control Observational Study.

Matthew A SpinelliMichael J PelusoKara L LynchCassandra YunDavid V GliddenTimothy J HenrichSteven G DeeksMonica Gandhi

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)

Following SARS-CoV-2 mRNA vaccination, people living with HIV (PLWH) had lower surrogate virus neutralization test response (p=0.03) and a trend towards lower IgG response (p=0.08), particularly among those with lower CD4+T-cell counts and who received the BNT162b2 vaccine. Study of the impact of supplemental vaccine doses among PLWH is needed.

Keyphrases

sars cov
case control
human immunodeficiency virus
antiretroviral therapy
hepatitis c virus
hiv aids
peripheral blood
hiv testing