Gut Microbially Produced Indole-3-Propionic Acid Inhibits Atherosclerosis by Promoting Reverse Cholesterol Transport and Its Deficiency Is Causally Related to Atherosclerotic Cardiovascular Disease.

Hongliang XueXu ChenChao YuYuqing DengYuan ZhangShen ChenXuechen ChenKe ChenYan YangWenhua Ling

Published in: Circulation research (2022)

Our study identify a previously unknown link between specific gut microbiota-derived tryptophan metabolite and ASCVD. The microbial metabolite IPA/miR-142-5p/ABCA1 pathway may represent a promising therapeutic target for ASCVD.

Keyphrases

cardiovascular disease
microbial community
type diabetes
cardiovascular risk factors
cardiovascular events
low density lipoprotein
coronary artery disease
replacement therapy