Identification of specifically reduced Th2 cell subsets in allergic rhinitis patients after sublingual immunotherapy.

F IharaDaiju SakuraiS YonekuraTomohisa IinumaR YagiT SakuraiT ItoA MatsuuraY MorimotoT AraiS SuzukiK KatayamaT NakayamaY Okamoto

Published in: Allergy (2019)

Allergen-reactive ST2+ CD45RO+ CD4+ cells or those combined with IL-5+ IL-13+ CD27- CD161+ CD4+ cells may be useful as markers indicating the successful treatment of SLIT. These cells may play a crucial role in the pathogenesis of AR as pathogenic memory Th2 cells.

Keyphrases

induced apoptosis
allergic rhinitis
end stage renal disease
endoplasmic reticulum stress
chronic kidney disease
signaling pathway
stem cells
oxidative stress
ejection fraction
bone marrow
cell therapy