Deletion of Endothelial TRPV4 Protects Heart From Pressure Overload-Induced Hypertrophy.
Ravi K AdapalaVenkatesh KatariAnantha K KanugulaVahagn OhanyanSailaja ParuchuriCharles K ThodetiPublished in: Hypertension (Dallas, Tex. : 1979) (2023)
Our results suggest that endothelial TRPV4 acts as a mechanical break for coronary angiogenesis, and uncoupling endothelial TRPV4 mechanotransduction attenuates pathological cardiac hypertrophy by enhancing coronary angiogenesis.