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Deletion of Endothelial TRPV4 Protects Heart From Pressure Overload-Induced Hypertrophy.

Ravi K AdapalaVenkatesh KatariAnantha K KanugulaVahagn OhanyanSailaja ParuchuriCharles K Thodeti
Published in: Hypertension (Dallas, Tex. : 1979) (2023)
Our results suggest that endothelial TRPV4 acts as a mechanical break for coronary angiogenesis, and uncoupling endothelial TRPV4 mechanotransduction attenuates pathological cardiac hypertrophy by enhancing coronary angiogenesis.
Keyphrases
  • endothelial cells
  • high glucose
  • coronary artery disease
  • coronary artery
  • neuropathic pain
  • vascular endothelial growth factor
  • aortic stenosis
  • diabetic rats
  • spinal cord
  • nitric oxide synthase
  • ejection fraction