Copper(I)-Catalyzed Chemoselective Coupling of Cyclopropanols with Diazoesters: Ring-Opening C-C Bond Formations.

Hang ZhangGuojiao WuHeng YiTong SunBo WangYan ZhangGuangbin DongJianbo Wang

Published in: Angewandte Chemie (International ed. in English) (2017)

Reported herein is an exceptional chemoselective ring-opening/C(sp3 )-C(sp3 ) bond formation in the copper(I)-catalyzed reaction of cyclopropanols with diazo esters. The conventional O-H insertion product is essentially suppressed by judicious choice of reaction conditions. DFT calculations provide insights into the reaction mechanism and the rationale for this unusual chemoselectivity.

Keyphrases

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