[PET/CT with 11C-methionine in assessment of brain glioma metabolism].
N B VikhrovaD B KalaevaA N TyurinaArtem Yu BelyaevGleb V DanilovI N ProninPublished in: Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko (2024)
We found variable 11C-MET metabolism in WHO 2021 gliomas and confirmed significant difference in metabolic activity and volume of 11C-MET accumulation in glioblastomas compared to IDH «+» gliomas. Moreover, we revealed the relationship between high accumulation index and shorter survival. Analysis of 11C-MET metabolism in patients over 50 years old revealed higher accumulation index in the EGFR «+» group. Further comparison of these imaging methods and assessment of other significant mutations are necessary to identify the anatomical and metabolic patterns of IDH «+» gliomas.
Keyphrases
- pet ct
- high grade
- tyrosine kinase
- low grade
- end stage renal disease
- ejection fraction
- small cell lung cancer
- single cell
- chronic kidney disease
- newly diagnosed
- epidermal growth factor receptor
- high resolution
- positron emission tomography
- prognostic factors
- computed tomography
- patient reported outcomes
- wild type
- cerebral ischemia
- amino acid