Hypoxia preconditioned bone marrow-derived mesenchymal stromal/stem cells enhance myoblast fusion and skeletal muscle regeneration.

Karolina ArchackaIwona GrabowskaBartosz MierzejewskiJoanna GraffsteinAlicja GórzyńskaMarta KrawczykAnna M RóżyckaIlona KalaszczyńskaGabriela MurasWładysława StremińskaKatarzyna Jańczyk-IlachPiotr WalczakMirosław JanowskiMaria A CiemerychEdyta Brzoska

Published in: Stem cell research & therapy (2021)

We suggested that SDF-1 and VEGF secreted by hypoxia preconditioned bone marrow-derived MSCs played an essential role in cell engraftment and angiogenesis. Importantly, hypoxia preconditioned bone marrow-derived MSCs more efficiently engrafted injured muscles; however, they did not undergo myogenic differentiation.

Keyphrases

stem cells
mesenchymal stem cells
endothelial cells
skeletal muscle
bone marrow
cell therapy
umbilical cord
vascular endothelial growth factor
single cell
type diabetes