miR-125b-5p delivered by adipose-derived stem cell exosomes alleviates hypertrophic scarring by suppressing Smad2.

Chaolei XuHao ZhangChen YangYing WangKejia WangRui WangWei ZhangChao LiChenyang TianChao HanMengyang LiXu LiuYunwei WangYan LiJian ZhangYu LiLiang LuoYage ShangLixia ZhangYuxi ChenKuo ShenDahai Hu

Published in: Burns & trauma (2024)

We found that ADSC exosomes could alleviate hypertrophic scars via the suppression of Smad2 by the specific delivery of miR-125b-5p.

Keyphrases

stem cells
transforming growth factor
epithelial mesenchymal transition
mesenchymal stem cells
cell therapy
mouse model
platelet rich plasma
bone marrow
signaling pathway