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Surfactant protein D multimerization and gene polymorphism in COPD and asthma.

Dalia FakihZeina AkikiKirsten JunkerMyrna Medlej-HashimMirna WakedPascale SalamehUffe HolmskovHasnaa Bouharoun-TayounSoulaima ChamatGrith L SorensenRania Jounblat
Published in: Respirology (Carlton, Vic.) (2017)
Collectively, non-multimerized species of serum SP-D were dominant in COPD and asthmatic patients suggesting that degradation of SP-D takes place to a significant degree in pulmonary disease. Assays that can separate SP-D proteolytic breakdown products or modified forms from naturally occurring SP-D trimers may result in optimal disease markers for pulmonary inflammatory diseases.
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