A base-promoted tandem approach to bicyclic 8-membered ring ketones.
Emerson E F Dos SantosGabriela Freitas Pereira de SouzaDeborah A SimoniAirton G SallesPublished in: Organic & biomolecular chemistry (2021)
A base-promoted tandem route toward unprecedented bicyclic 8-membered ring ketones is reported. Under our approach, the targeted products are delivered in high yields from phenylacetylenes and 1,3-diketones. The method has a good scope and gives access to a complex structure that offers a wealth of opportunities for further functionalization.
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