Metabolomic signatures distinguish the impact of formula carbohydrates on disease outcome in a preterm piglet model of NEC.

Lee CallBarbara StollBerthe OosterlooNadim AjamiFariha SheikhAnja WittkeRosaline WaworuntuBrian BergJoseph PetrosinoOluyinka OlutoyeDouglas G Burrin

Published in: Microbiome (2018)

Feeding formula containing lactose is not completely protective against NEC, yet selects for greater microbial richness associated with changes in Bacilli and Clostridium and lower NEC incidence. We conclude that feeding preterm piglets a corn syrup solid vs. lactose-based formula increases the incidence of NEC and produces distinct metabolomic signatures despite modest changes in microbiome profiles.

Keyphrases

human milk
low birth weight
risk factors
preterm birth
preterm infants
gestational age
genome wide
microbial community
gram negative
gene expression
dna methylation
multidrug resistant