Flow-cytometric microglial sorting coupled with quantitative proteomics identifies moesin as a highly-abundant microglial protein with relevance to Alzheimer's disease.
Sruti RayaproluTianwen GaoHailian XiaoSupriya RameshaLaura D WeinstockJheel ShahDuc M DuongEric B DammerJames A WebsterJames J LahLevi B WoodRanjita BetarbetAllan I LeveyNicholas T SeyfriedSrikant RangarajuPublished in: Molecular neurodegeneration (2020)
Using FACS coupled with TMT-MS as the method of choice for microglial proteomics, we define a core set of highly-abundant adult microglial proteins. Among these, we validate Msn as highly-abundant in plaque-associated microglia with relevance to human AD.