Short- and long-term effects of body weight, calorie restriction and gastric bypass on CYP1A2, CYP2C19 and CYP2C9 activity.
Kine Eide KvitneVeronica KrogstadChristine WeglerLine Kristin JohnsonMarianne K KringenMarkus Herberg HovdJens K HertelMaria HeijerRune SandbuEva SkovlundPer ArturssonCecilia KarlssonShalini AnderssonTommy B AnderssonJøran HjelmesaethAnders AsbergRasmus Jansson-LöfmarkHege ChristensenIda RobertsenPublished in: British journal of clinical pharmacology (2022)
Our findings suggest that CYP2C19 activity is lower in patients with obesity and increases following weight loss. This may be clinically relevant for drug dosing. No clinically significant effect on CYP1A2 and CYP2C9 activities was observed.