In utero exposure to thiopurines/anti-TNF agents and long-term health outcomes during childhood and adolescence in Denmark.

Bente Mertz Nørgård Jan Nielsen Sonia Friedman

Published in: Alimentary pharmacology & therapeutics (2020)

After in utero exposure to thiopurines, we found no increased risk of infections, psychiatric diagnoses/ASD/ADHD, or malignancies during childhood/adolescence. After in utero exposure to anti-TNF medications, the risk of respiratory, urological/gynaecological infections and other infections was increased during the first year of life.

Keyphrases

autism spectrum disorder
attention deficit hyperactivity disorder
rheumatoid arthritis
depressive symptoms
working memory
early life
intellectual disability