Modular Domino Process toward Highly Functionalized Pyrroles via Pd-Catalyzed [4 + 1] Annulation under Mild Conditions.
Linhong ZuoYulian YangWusheng GuoPublished in: Organic letters (2021)
A Pd-catalyzed decarboxylative approach for the modular synthesis of highly functionalized pyrroles is presented. This protocol utilizes readily available cyclic carbonates and amines as reaction partners and only generates CO2 and H2O as byproducts. This methodology could be operated at room temperature and open to air, thus serving as an ideal means for the derivatization of bioactive compounds. Mechanism investigations suggested that the stereoselective formation of the (Z)-configured γ-amino ketone intermediate is crucial for the success of the reaction.
Keyphrases
- room temperature
- quantum dots
- ionic liquid
- molecularly imprinted
- ms ms
- drinking water
- minimally invasive
- liquid chromatography tandem mass spectrometry
- high performance liquid chromatography
- gas chromatography mass spectrometry
- simultaneous determination
- solid phase extraction
- electron transfer
- tandem mass spectrometry
- high resolution
- ultra high performance liquid chromatography